By lowering the concentration of carnitine synthesis is enhanced gamma-butyrobetaine, which has vasodilatory properties. The mechanism of action determines the variety of pharmacological effects meldonium: improving efficiency, dianabol before and after reducing the symptoms of mental and physical stress, activation of tissue and humoral immunity, cardioprotective effect. In the case of acute ischemic myocardial damage slows the formation of necrotic areas, shorten the rehabilitation period. In heart failure increases the contractility of the myocardium, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebrovascular disorders improves blood circulation in the ischemic focus, promotes redistribution of blood to the ischemic area. It is effective in the case of vascular and dystrophic pathology of the ocular fundus. It is also characteristic toning effects on the central nervous system, elimination of functional disturbances of somatic and autonomic nervous system in patients with chronic alcoholism during abstinence.
After intake of rapidly absorbed, bioavailability of 78%. The maximum plasma concentration is reached 1-2 hours after ingestion. It is metabolized in the body into two major metabolites which the kidneys.The half-life when administered dose-dependent and is 3-6 hours.
Indications in neurology in the complex therapy: ischemic stroke, hemorrhagic stroke in the recovery period, transient ischemic attacks, chronic cerebrovascular insufficiency. In cardiology in the treatment of: coronary heart disease (angina, myocardial infarction), congestive heart failure, dyshormonal cardiomyopathy . The reduced efficiency; physical stress, including in athletes; to accelerate postoperative rehabilitation. abstinent alcoholic syndrome (in combination with specific therapy).
With care in diseases of the liver and / or kidneys.
Increased intracranial pressure (in violation of the venous outflow and intracranial tumors). Pregnancy dianabol before and after and lactation. Children under 18 years old.
Dosing and Administration
Inside the cerebral circulation: in the acute phase of cerebrovascular pathology used injectable form of the drug for 10 days, and then designate the interior of 500 mg per day. The course of treatment – 4-6 weeks. Chronic disorders of cerebral circulation: 500 mg 1 time per day, preferably in the morning. The course of treatment – 4-6 weeks. Repeated courses – 2-3 times a year. In cardiology in the treatment of:500 mg to 1 g per day. The course of treatment – 4-6 weeks. Cardialgia on background dyshormonal dystrophy infarction: 250 mg 2 times a day (morning and evening). The course of treatment – 12 days. The mental and physical overload (including the athletes) adult 250 mg 4 times a day. The course of treatment – 10-14 days. If necessary, repeat the treatment after 2-3 weeks. At 500 mg, 1 g, 2 times a day before training, preferably in the morning. . The duration of the preparatory period – 14-21 days, during the period of competition – 10-14 days of alcohol withdrawal syndrome: 500 mg 4 times a day. The course of treatment – 7-10 days.
Side effects are
rare – allergic reactions (itching, rash, redness and swelling of the face), indigestion, tachycardia, agitation, decreased blood pressure.
Cases of overdose have not been established.
Interaction with other medicines
Do not use simultaneously with other dosage forms containing meldonium (the risk of side effects).
Increases the vasodilatig and some antihypertensive drugs, cardiac glycosides.
In view of the possible development of mild tachycardia and hypotension, caution should be exercised when combined with nitroglycerin, nifedipine, alpha-blockers, antihypertensive agents and peripheral vasodilators.
It can be combined with antianginal drugs, anticoagulants, antiplatelet agents, antiarrhythmic agents, dianabol before and after diuretics, bronchodilators. anabolic steroids online shop
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