Muscle relaxants centrally acting. The mechanism of action is not fully understood. It has a membrane, local anesthetic effect, slows the pulse conduction in the fibers and primary afferent motor neurons which leads to blocking of mono- and polysynaptic spinal reflexes. Also, perhaps, secondarily inhibits the release of mediators by inhibiting dianabol dosage in the synapses. The brain stem eliminates the relief of excitation by reticulospinal way. Enhances peripheral blood flow, regardless of the influence of the central nervous system. In the development of this effect plays the role of a weak antispasmodic and adrenobpokiruyuschy effect of tolperisone. After oral tolperisone is well absorbed from the gastrointestinal tract.The maximum concentration is reached after 0.5-1 hours, bioavailability is about 20%. Tolperisone is metabolised in the liver and kidneys. Withdrawal takes place through the kidneys as metabolites (more than 99%). The pharmacological activity unknown metabolites.
Treatment of pathologically increased tone and spasm of the striated muscle, resulting from organic diseases of the central nervous system (pyramidal tract damage, multiple sclerosis, stroke, myelopathy, encephalomyelitis etc.).
Treating high tone and muscle spasms, muscle contractures, accompanying diseases of the musculoskeletal system (spondylosis, spondylarthritis, cervical and lumbar syndromes, arthrosis of large joints).
Medical rehabilitation after orthopedic and trauma operations.
In the combination therapy of obliterating vascular disease (atherosclerosis, diabetic angiopathy, thromboangiitis obliterans, Raynaud’s disease ), diseases caused by disorders of vascular innervation (akrotsianoz, intermittent angioneurotic disbaziya).
clung disease (children’s cerebral palsy), and other encephalopathy, accompanied by muscular dystonia.
To avoid complications be used strictly on prescription!
: Hypersensitivity to one of the components of the preparation. Myasthenia gravis, children up to 1 year.
Pregnancy and lactation
During pregnancy and lactation (breastfeeding) dianabol dosage can be used (especially in the first trimester of pregnancy) only if the expected benefit exceeds the risk of potential complications to the fetus.
Dosing and Administration
Inside, the food, without chewing, with a small amount of water. Adults: Usually starting with 50 mg 2-3 times a day, gradually increasing the dose to 150 mg 2-3 times a day.
Muscle weakness, headache, decreased blood pressure, nausea, vomiting, abdominal discomfort. As the dose side effects are usually held.
In rare cases, allergic reaction occurs (pruritus, erythema, urticaria, angioedema, anaphylactic shock, bronchospasm).
Overdose dianabol dosage have been reported.
Broad therapeutic range in the literature, even the oral administration of the drug at a dose of 600 mg in children without symptoms of more serious toxic effects. When taken orally 300-600 mg per day in pediatric patients, in some cases we observed irritability. In experiments on the toxicity on animals, high doses of the drug caused ataxia, tonic and clonic convulsions, shortness of breath and respiratory paralysis.
No specific antidote is recommended gastric lavage if the drug overdose, general symptomatic and supportive treatment.
Interaction with other medicinal products
interaction data, limiting, are not available.
Although tolperisone has an effect on the central nervous system, it does not cause sedation, so it can be used in combination with sedatives, hypnotics and drugs containing alcohol.
Does not affect the . the effect of alcohol on the central nervous system of
tolperisone nifluminovoy enhances the action of acids, while the use of these drugs may require dose reduction nifluminovoy acid.
general anesthetics, peripheral muscle relaxants, psychotropic drugs, clonidine – enhance the effect of tolperisone. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.